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2026-06-29 13:51:49 -

The Accidental Molecule: How a Failed Heart Drug Became the World's Most Famous Pill

In the early 1990s, in a clinical trial run out of a Pfizer laboratory in the south of England, a group of male volunteers were testing a new compound meant to treat angina—the crushing chest pain of a heart starved of blood. The molecule, dryly labeled UK-92,480, was supposed to relax the vessels feeding the heart. It barely did. By most measures, the trial was a disappointment. Then the...

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